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Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

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Respiratory complex I is a multi-subunit membrane protein complex that reversibly couples NADH oxidation and ubiquinone reduction with proton translocation against transmembrane potential. Complex I from Escherichia coli is among the best functionally characterized complexes. but its structure remains unknown. hindering further studies to understand the enzyme coupling mechanism. https://www.roneverhart.com/M-M-s-Peanut-Bulk-25LB-Case/
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